Location: United States
Cap-Exempt H-1B Position — No lottery required
**Job Title:** Postdoctoral Fellow – Spatial and Single-Cell Multi-Omics **Introduction:** We are seeking a highly motivated Postdoctoral Fellow to join our team and play a key role in developing, optimizing, and applying spatial and single-cell multi-omic technologies. The successful candidate will contribute to experimental method development, sequencing-based assay optimization, and associated computational analyses to study gene regulation, chromatin organization, and epigenomic mechanisms in complex biological systems. This position is ideal for a candidate with strong interests in technology development, single-cell/spatial genomics, epigenomics, and integrative analysis. The fellow will work closely with experimental and computational scientists in a highly collaborative environment and will have opportunities to lead independent projects, publish high-impact studies, and develop new tools for the broader research community. **Key Responsibilities:** **Spatial and Single-Cell Method Development:** Develop, optimize, and benchmark new spatial and single-cell multi-omic assays, including approaches that integrate transcriptomic, epigenomic, chromatin accessibility, DNA methylation, chromatin conformation, and/or protein-level measurements. **Experimental Optimization and Troubleshooting:** Design and perform experiments to improve assay sensitivity, throughput, robustness, and compatibility with primary tissues, low-input samples, and clinically relevant specimens. Optimize sample preparation, nuclei/cell isolation, library construction, sequencing strategies, and quality-control steps. **Multi-Omic Data Generation and Analysis:** Generate and analyze spatial and single-cell datasets, including single-cell RNA-seq, single-cell epigenomic assays, spatial transcriptomics, and other multi-omic platforms. Perform quality control, normalization, clustering, annotation, differential analysis, trajectory analysis, and regulatory feature identification. **Data Integrat