Location: Cambridge, MA
Cap-Exempt H-1B Position — No lottery required
**Classification:** Exempt **Job Family:** Core Facilities **Reports to:** Director Genome Technology Core **Job Description Summary:** OVERALL RESPONSIBILITY The Genomics Technology Core Technician serves as a central point of expertise for sequencing and analytical operations. This role bridges wet-lab execution and computational analysis, supporting both short- and long-read sequencing workflows. The Technician will help internal and external clients on sequencing technologies, guide project design, manage client communication, and deliver rigorous data pre-processing, quality control, and downstream analysis. Will contribute to hands-on support in the laboratory as needed. **CHARACTERISTIC DUTIES** - Advise clients on appropriate sequencing technologies (short-read, long-read, single-cell, spatial) and help define project parameters, expected outputs, and deliverables. - Perform primary NGS data processing including demultiplexing, alignment, and quality assessment (FastQC, MultiQC, etc.). - Conduct secondary analysis as required, including variant calling, differential expression, or genome assembly depending on project needs. - Develop and maintain reproducible analysis pipelines. - Use and update LIMS and genomics databases to track samples, datasets, and project metadata. - Communicate effectively with researchers at all levels to ensure deliverables meet scientific objectives. - Document protocols, analysis workflows, and results clearly for both technical and non-technical audiences. - Assist with NGS related services, quality control (Bioanalyzer, TapeStation, Qubit), and sequencer operation as needed. - Contribute to continuous improvement of core facility processes and standard operating procedures. - Other tasks, as required. **QUALIFICATIONS** **Required** - BS in Molecular Biology, Bioinformatics, Computational Biology, or a related field; or equivalent experience. - 3+ years of relevant hands-on experience. - Demonstrated expertise coordinating NGS