Location: Cambridge, MA
Cap-Exempt H-1B Position — No lottery required
### **General information** Location Cambridge, MA Ref # 44166 Job Family Research Workplace Hybrid Date published 05/20/2026 Time Type Full time Pay Range $88,000.00/yr - $124,000.00/yr ### **Description & Requirements** The Talkowski Laboratory in the Center for Genomic Medicine at Massachusetts General Hospital (MGH) and the Broad Institute of MIT and Harvard is seeking a highly motivated, enthusiastic Computational Scientist to work with and support our research group in analyzing sequencing data to identify structural variants within the human genome using genomic population databases and aggregating phenotype and genotype datasets. We are comprised of an interdisciplinary group of scientists, technicians, bioinformaticians, computational biologists, and postdoctoral fellows who work together in a mutually supportive and respectful environment. Ideas are freely shared, and contributions are highly valued. We are dedicated to characterizing genomic variation contributing to human disease, with a focus on the relationship between genome structure and function. The lab integrates molecular and computational genomics methods to investigate the genetic architecture of neuropsychiatric disorders and develop new technologies for translational applications in genetic diagnostics. The lab has served as a hub for novel gene and variant discovery and functional genomics modeling in common complex and rare Mendelian disorders. At a minimum, candidates should have a PhD in genetics or a related field. Additional postdoctoral experience is preferred, but not required. Candidates should have a deep computational background, including experience in statistical genetics, programming languages, and data science. They should excel at critical thinking, performing large-scale analyses, and demonstrate an ability to learn, develop, and apply new computational tools and methods. They will seek to understand which models and tools would drive progress on core scientific questions, le