Location: Seattle, WA
Cap-Exempt H-1B Position — No lottery required
***Research Associate I – Brain Health*** The **mission** of the **Allen****Institute** is to understand the principles that govern life and to advance health. Our creative and multi-dimensional teams focus on answering some of the biggest questions in bioscience. We accelerate foundational research, catalyze bold ideas, develop tools and models, and openly share our science to make a broad, transformational impact on the world. The **Allen Institute** is launching a new initiative on human brain health and disease. This initiative aims to dramatically accelerate our understanding of human brain structure and function, identify the molecular, cellular and circuit basis of disease progression, and pioneer new therapeutic strategies targeting vulnerable and affected cell types. Our mission focuses on taking a human-centric approach to understanding and treating disease, combining a large-scale open science discovery approach across multiple diseases, AI-based disease modeling, and translational programs in specific diseases to move from discovery to clinical application. We aim to make transformational change in understanding and treating brain disorders, the biggest health challenge of our time. We seek an outstanding **Research Associate I** to join the Brain Health team to conduct investigational studies of the impact of novel interventions on the molecular, cellular and behavioral progression of Huntington’s Disease mouse models and cell culture systems. The specific intervention being tested in this project involves treating mice with virally delivered experimental constructs, to establish the extent to which different versions of these constructs ameliorate Huntington’s Disease relevant phenotypes in live mice and tissues derived from them. In parallel to these mouse experiments, the candidate will conduct cell culture experiments in immortalized mammalian cell culture to test novel Huntington’s Disease treatment strategies using molecular and microscopic analys