Location: Boston, MA
Cap-Exempt H-1B Position — No lottery required
Job Ref: JR-2725 Location: 450 Brookline Ave, BOSTON, MA 02215 Category: IT/Informatics Employment Type: Full time Work Location: Onsite: occasional remote Salary/Pay Rate: $75,000.00 - $91,500.00 per year **Overview** Dana-Farber Cancer Institute/HHMI/Harvard Medical School/Broad Institute- Computational Biology Position in the Kadoch Laboratory Kadoch Laboratory Chromatin and gene regulation in human disease The Kadoch Laboratory at the Dana-Farber Cancer Institute, Harvard Medical School, Broad Institute, and Howard Hughes Medical Institute is seeking a highly qualified individual who has recently obtained or is about to obtain a BA/BS degree to join our vibrant research team as a Computational Biologist focused on cancer biology, epigenetics, and chromatin regulation. Our lab uses multidisciplinary approaches including biochemistry, biophysics, structural biology, chemical biology, and functional genomics, epigenomics, and AI-based approaches to explore the mechanisms of chromatin remodeling complexes, which are among the most frequently mutated cellular entities in human cancers and other diseases. As such, our computationally centered projects in the lab are highly diverse and involve extensive genomics (i.e. analysis of diverse sequencing methods including DNA-sequencing, RNA-sequencing (RNA-seq), ATAC-seq, ChIP-seq, CUT&RUN, CUT&TAG, single-cell ATAC+RNA-seq, among other approaches), analysis of functional screening datasets (i.e. genome-wide as well as targeted CRISPR- and base editing-based screens for cell fitness or other cellular outcomes), 3D structural biology (i.e. use of Pymol, UCSF Chimera for structural analysis, mapping mutations, etc.), analysis and integration of mass-spectrometry proteomics datasets, and artificial intelligence/machine learning (AI/ML) and systems-biology-focused efforts (i.e. large genomics and proteomics dataset analysis and integration, Deep Mind Alphafold, Rosetta, other approaches). Our exciting collection of ongoing proj