Location: New York, NY
Cap-Exempt H-1B Position — No lottery required
Department: Academic Program Location: New York, NY ##### **Job details** **About Us:** The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursue our mission at MSK and around the globe. Join the **Lee Lab: Cancer Genome History & Therapeutics** at MSK. We study the mutational processes and genomic rearrangements that drive cancer evolution and therapy resistance using high-throughput sequencing as the main toolkit. We are seeking a highly motivated postdoctoral fellow with strong expertise in computational biology to lead projects at the interface of cancer biology, single-cell genomics, and clinical oncology. **Project focus:** You will analyze single-cell whole-genome sequencing data jointly with other multi-omic datasets from i) genetically engineered mouse models, ii) PDX/PDO systems, and iii) clinical tumor samples to define evolutionary trajectories of extrachromosomal circular DNA-mediated oncogene amplification. This position offers a unique opportunity to work in a highly collaborative and translational environment, closely partnering with experimental scientists and clinician investigators. The position is supported by a grant from the Burroughs Wellcome Fund. https://www.mskcc.org/profile/jake-june-koo-lee **What you will do:** - Lead computational analyses of high-throughput sequencing datasets, including scWGS and multi-omic datasets - Apply/adapt/develop novel computational approaches to study mutational proce