Location: New Haven, CT
Cap-Exempt H-1B Position — No lottery required
Working at Yale means contributing to a better tomorrow. Whether you are a current resident of our New Haven-based community, eligible for opportunities through the New Haven Hiring Initiative, or a newcomer, interested in exploring all that Yale has to offer, your talents and contributions are welcome. Discover your opportunities at Yale! **Overview** The Chemical Metabolism Core is seeking a highly motivated and experienced analytical chemist/mass spectrometrist to join our team. The successful candidate will play a critical role in developing, validating, and applying targeted and untargeted LC‑MS/MS methods (including stable isotope tracing, metabolomics, and lipidomics) to support internal and external research projects across diverse disease areas. This position is primarily hands‑on at the bench and on instruments, with substantial responsibility for method development, quantitative assay deployment, and day‑to‑day operation of multiple LC‑MS platforms in a shared core environment. Skills & Responsibilities: General Skills - Lead development, validation, and documentation of quantitative LC‑MS/MS assays (calibration curve design, QC strategy, acceptance criteria, carryover evaluation, matrix effects, and stability assessments) suitable for multi‑user core deployment. - Design and execute stable isotope tracer experiments (e.g., ¹³C‑glucose, ¹³C‑glutamine), including sample workup and downstream isotopologue data analysis (desired). - Support both discovery‑oriented metabolomics/lipidomics projects and hypothesis‑driven, targeted quantitation studies for a broad user base (faculty labs, trainees, external collaborators). - Coordinate sample intake, batching, and queue management, and communicate timelines, data quality issues, and results clearly to users with varying levels of technical expertise. Instrumentation and Technical Skills - Hands‑on experience operating, maintaining, and troubleshooting high‑resolution and/or triple quadrupole LC‑MS systems (e.g.,